Table 3.
Reported adverse events in Zambian adults given live, attenuated oral vaccines.
| Rotavirus |
ETEC |
Vivotif |
Total vaccinated |
P | |||||
|---|---|---|---|---|---|---|---|---|---|
| HIV+ (n = 9) | HIV− (n = 15) | HIV+ (n = 7) | HIV− (n = 14) | HIV+ (n = 42) | HIV− (n = 39) | HIV+ (n = 58) | HIV− (n = 68) | ||
| Diarrhoea (within 7 days of last dose of vaccine) | 0 | 0 | 0 | 0 | 5 | 1 | 5 | 1 | 0.09 |
| Diarrhoea (within 28 days of first dose of vaccine) | 0 | 0 | 3 | 1 | 6a | 1 | 9 | 2 | 0.04 |
| Abdominal pain | 0 | 0 | 0 | 0 | 3 | 0 | 3 | 0 | 0.09 |
| Fever | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1.00 |
| Loss of appetite | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1.00 |
| Nausea/vomiting | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – |
| Fall in Hb > 1 g/dl | 3 | 2 | 0 | 3 | 4 | 3 | 7 | 8 | 1.00 |
| Fall in WBC >1 × 109/l | 0 | 3 | 1 | 0 | 7 | 7 | 8 | 10 | 1.00 |
The P value shown relates to HIV seropositive vs. seronegative participants (i.e. not including the second episode of diarrhoea in that vaccinee who experienced two episodes) in the total group of those vaccinated, using Fisher's exact test.
a
Two of these episodes were in the same vaccinee.