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Repair of AP site initiated by Tdp1 in DNA duplexes containing AP site in cluster with bulky lesion. The 5′-end labeled AP-DNA substrate was subsequently incubated with the UDG (lane 2), Tdp1 (lane 3), PNKP and XRCC1 (lane 4), Pol β (lane 5), DNA ligase III (lane 6) to monitor DNA repair. Lane 1 corresponds to the AP-DNA. The components present in different reaction mixtures are indicated.
