Table 2.
Percentile Changes of Patients' Weight at Different Reference Periods Stratified by Type of Drugs
| |
From 0 to 6 months(n 296 MPH; n 294 ATX)Percentile |
From 0 to 12 months(n 184 MPH; n 159 ATX)Percentile |
From 0 to 24 months(n 55 MPH; n 28 ATX)Percentile |
||||||
|---|---|---|---|---|---|---|---|---|---|
| decreased | unchanged | increased | decreased | unchanged | increased | decreased | unchanged | increased | |
| Methylphenidate (MPH) | 83 (28.1%) | 178 (60.1%) | 35 (11.8%) | 58 (31.5%) | 92 (50.0%) | 34 (18.5%) | 23 (41.8%) | 17 (30.9%) | 15 (27.3%) |
| Binomial | test | p<0.001 | Binomial | test | p=0.018 | Binomial | test | p=0.267 | |
| Atomoxetine (ATX) | 112 (38.1%) | 158 (53.7%) | 24 (8.2%) | 73 (45.9%) | 63 (39.6%) | 23 (14.5%) | 15 (53.6%) | 9 (32.1%) | 4 (14.3%) |
| Binomial | test | p<0.001 | Binomial | test | p<0.001 | Binomial | test | p=0.010 | |
| MPH vs ATX | χ2=7.43 | df=2 | p=0.024 | χ2=7.48 | df=2 | p=0.024 | χ2=1.94 | df=2 | p=0.380 |
The binomial test refers to the comparison between frequencies of percentile decreased and increased subjects, based on the null hypothesis of equal distribution between the two categories.
The χ2 test refers to the comparison between the distributions of MPH- and ATX-treated subjects in the percentile change categories.
df, degrees of freedom.