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. 2013 Mar;1832(3):445–452. doi: 10.1016/j.bbadis.2012.12.002

Fig. 1.

Fig. 1

Brain MRI: (A) 31-year-old, FLAIR T2-weighted axial image shows bilateral and symmetrical hyperintensities of the vestibular nuclei (arrows); (B) 33-year-old, FLAIR T2-weighted axial image shows increased volume and increased signal intensity of the right inferior colliculus (arrow); (C) 35-year-old, FSPGR-T1-weighted axial image shows hypointense signal changes of both inferior colliculi (arrows), consistent with cystic necrotic lesions. OCT analysis of RNFL thickness (Cirrus, Carl Zeiss Meditec) and fundus color pictures of the patient at 3 years follow-up. OCT shows a diffuse thinning of RNFL thickness corresponding to complete atrophy of the optic nerve as shown by pallor of the optic disc at fundus pictures (D).