Fig. 4.

Correlation of the expression of Dll4-Notch signaling components with clinical parameters. The fold of change refers to the relative expression of the individual genes and was calculated on the basis of the expression of the internal reference gene GAPDH and in the relation to the control samples (normal brain). MGMT positive/negative: O6-methylguanine-methyltransferase promoter methylation positive/negative status; KPI: Karnofsky performance index. A KPI >70 is indicative of a better preoperative condition of the patient. *P < .05 and **P < .01, compared with normal control brains.