Fig. 9.

Model depicting role of miR-145 on cell cycle progression and invasion in glioma cells. The levels of miR-145 are downregulated in glioma cells. Sox9 and ADD3 levels inversely correlate with miR-145 expression in glioma cell lines, as they are the direct targets of miR-145. The downregulation of Sox9 can suppress the transcription of cell cycle progression–related genes (c-Myc, N-myc, cyclin D1) and cause accumulation of cells in G1 phase leading to inhibition of cell cycle progression. The attenuation of ADD3 levels can downregulate expression of genes involved in cell migration (E-cadherin, N-cadherin), resulting in inhibiting GBM cell invasion.