Table 3.
Overview of cognitive tests administered and results of comparisons between the baseline assessment and the modafinil and placebo conditions for cognitive functioning
| Baseline n = 36 M (SD) | Modafinil n = 25 M (SD) | Placebo n = 28 M (SD) | Baseline vs Modafinil z (P) | Baseline vs Placebo z (P) | Modafinil vs Placebo z (P) |
|---|---|---|---|---|---|
| Verbal memory | |||||
| Auditory Verbal Learning Test (AVLT)45 | |||||
| 0.00 (0.71) | 0.14 (0.86) | −0.12 (1.02) | −1.63 (.104) | −0.29 (.767) | −1.60 (.110) |
| Working memory | |||||
| Memory Comparison Test (MCT)46 | |||||
| 0.00 (0.86) | 0.24 (0.93) | 0.17 (0.90) | −2.06 (.040*) | −2.03 (.043*) | −1.26 (.209) |
| Attentional functioning | |||||
| Stroop Color Word Test47 | |||||
| 0.00 (1.04) | 0.15 (0.94) | 0.18 (0.75) | −1.28 (.201) | −2.44 (.015*) | −2.49 (.013*) |
| Information processing | |||||
| Letter Digit Substitution Test (LDST)48 | |||||
| 0.00 (0.94) | 0.36 (1.18) | 0.19 (1.12) | −2.01 (.036*) | −2.05 (.040*) | −0.24 (.808) |
| Executive functioning | |||||
| Concept Shifting Test (CST)49 | |||||
| Categorical Word Fluency Test (CWFT)50 | |||||
| 0.00 (0.80) | 0.19 (0.78) | 0.05 (0.94) | −1.17 (.242) | −1.25 (.210) | −0.03 (.977) |
| Psychomotor speed | |||||
| Concept Shifting Test40 | |||||
| Letter Digit Substitution Test48 | |||||
| 0.02 (0.61) | 0.26 (0.56) | 0.16 (0.53) | −1.60 (1.09) | −1.48 (.139) | −0.54 (.587) |
| Subjective cognitive functioning | |||||
| 31.79 (17.62) | 29.11 (16.04) | 27.49 (18.11) | −0.79 (.428) | −1.91 (.056) | −1.33 (.184) |
The cognitive domains included the following assessments: verbal memory: AVLT 1, AVLT recall, AVLT recognition, AVLT delta, AVLT total; working memory: MCT %, MCT 1, MCT 2, MCT 3, MCT4; attentional functioning: Stroop card 1, Stroop card 2, Stroop card 3; information processing: LDST reading, LDST writing; executive functioning: CST A, CST B, CST C, CWFT animals (60 s); psychomotor speed: CST 0, LDST delta.
*P < .05.