Table 3.
Median cognitive decline: standardized scores
| Memantine | Placebo | P* | |
|---|---|---|---|
| Week 8 | |||
| HVLT-R Total Recall | –0.465 | –0.62 | .3805 |
| HVLT-R Delayed Recall | –0.36 | –0.72 | .0692 |
| HVLT-R Delayed recognition | 0 | –0.71 | .0762 |
| TMT-A | 0 | –0.1 | .0848 |
| TMT-B | 0 | –0.35 | .2886 |
| COWA | –0.11 | –0.31 | .0513 |
| CTB Composite | –0.29 | –0.48 | .2157 |
| Week 16 | |||
| HVLT-R Total Recall | –0.62 | –0.615 | .3854 |
| HVLT-R Delayed Recall | –0.915 | –0.71 | .4109 |
| HVLT-R Delayed Recognition | 0 | 0 | .4541 |
| TMT-A | –0.2 | –0.285 | .4375 |
| TMT-B | –0.39 | –0.59 | .2470 |
| COWA | –0.05 | –0.42 | .0380 |
| CTB Composite | –0.335 | –0.45 | .1926 |
| Week 24 | |||
| HVLT-R Total Recall | –0.23 | –0.415 | .2093 |
| HVLT-R Delayed Recall | 0 | –0.895 | .0587 |
| HVLT-R Delayed Recognition | 0 | –0.715 | .0115 |
| TMT-A | 0.075 | –0.365 | .0237 |
| TMT-B | –0.45 | –0.49 | .2966 |
| COWA | –0.1 | –0.16 | .3080 |
| CTB Composite | –0.03 | –0.41 | .0212 |
Abbreviations: HVLT-R, Hopkins Verbal Learning Test-Revised; TMT-A, Trail Making Test Part A; TMT-B, Trail Making Test Part B; COWA, Controlled Oral Word Association; CTB, Clinical Trial Battery.
*Wilcoxon rank-sum test (one-sided).