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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: J Neurol Neurosurg Psychiatry. 2012 Oct 20;84(2):154–162. doi: 10.1136/jnnp-2011-302087

Figure 1.

Figure 1

Statistical p-maps show significant differences in brain volumes between the non-carrier (NC) group and mutation carriers with normal cognition (MUT-Norm), amnestic mild cognitive impairment (MUT-aMCI) and dementia (MUT-Dem) groups. (A) The MUT-Norm group demonstrated significantly smaller volumes (as indicated in brown colour) than the NC group in the caudate, putamen and thalamus. (B) The MUT-aMCI group exhibited significantly smaller volumes than the NC group in the thalamus, splenium and pons, and a trend for smaller volumes in the left temporal lobe. (C) The MUT-Dem group had significantly smaller volumes than the NC group in the bilateral temporal and parietal lobes, the left frontal lobe and putamen.