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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: J Neurol Neurosurg Psychiatry. 2012 Oct 20;84(2):154–162. doi: 10.1136/jnnp-2011-302087

Figure 2.

Figure 2

Jacobian maps of PSEN1 mutation carriers with normal cognition (PS1-MUT-Norm), amnestic MCI (PS1-MUT-aMCI) and dementia (PS1-MUT-Dem) were compared to that of non-carrier relatives of PSEN1 mutation carriers (PS1-NC). Significance p-maps show that (A) PS1-MUT-Norm subjects exhibited smaller volumes in the thalamus, striatum and right temporal region; (B) PS1-MUT-aMCI subjects exhibited smaller volumes in the thalamus, putamen, splenium and left temporal lobe; and (C) PS1-MUT-Dem groups exhibited smaller volumes in the putamen and temporal, parietal and left frontal regions.