. Author manuscript; available in PMC: 2014 Feb 1.

Published in final edited form as: J Neurol Neurosurg Psychiatry. 2012 Oct 20;84(2):154–162. doi: 10.1136/jnnp-2011-302087

Table 2.

Demographic characteristics for the NC, MUT-Norm, MUT-aMCI and MUT-Dem groups

Demographic variables	NC (n=10) Mean (SD)	MUT-Norm (n=9) Mean (SD)	MUT-aMCI (n=12) Mean (SD)	MUT-Dem (n=4) Mean (SD)	t or χ²	p Value
Age, years	38.1 (8.2)^a	29.9 (5.5)^b	35.1 (7.5)^c	50.5 (5.1)^abc	9.22	<0.001
Relative age, years	−6.9 (11.7)	−15.4 (5.4)^a	−10.4 (8.5)^b	5.0 (5.3)^ab	5.38	0.004
Education, years	13.7 (2.9)	13.1 (2.5)	10.5 (4.1)	12.3 (6.8)	1.50	0.24
Gender (m/f)	3/7	2/7	2/10	1/3	0.56	0.91
APOE genotype (e4, %)	2 (20%)	1 (11%)	1 (8%)	0 (0%)	1.36	0.72
Global functioning	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)	F_3,30	p Value
MMSE	28.9 (0.9)^ab	29.0 (0.5)^c	26.7 (2.9)^ad	11.8 (7.2)^bcd	24.42	<0.001
CDR	0.10 (0.2)^a	0.00 (0.00)^b	0.25 (0.3)^c	2.00 (0.8)^abc	24.00	<0.001

^abcd

Groups denoted by same letters differ by p<0.05.

Group differences in age, relative age and education were assessed using analysis of variance. Differences in gender distribution were assessed using Pearson χ² tests. Differences in MMSE and CDR scores were assessed using analysis of covariance, controlled for age.

APOE, apolipoprotein E; CDR,clinical dementia rating; MMSE, mini-mental state examination; MUT-aMCI, mutation carriers with amnestic mild cognitive impairment; MUT-Dem, mutation carriers with dementia; MUT-Norm, mutation carriers with normal cognition; NC, non-carriers.