Skip to main content
. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Anesthesiology. 2013 Mar;118(3):527–536. doi: 10.1097/ALN.0b013e3182834d94

Figure 5. Clodrolip effect and early kinetic of the mRNA hippocampal expression of IL-1β, TNF-α, IL-6 and MCP-1 after tibia fracture.

Figure 5

A. Hippocampal mRNA expression of IL-6 relatively expressed as fold increase compared to control brain expression, 12 and 24 h after tibia fracture in the CT-lip and the clodrolip-treated mice (n = 6 per group and per timing, two-way ANOVA, P = 0.0003 for the treatment effect, P = 0.0023 for the time effect, P = 0.51 for interaction). B. Hippocampal mRNA expression of TNF-α relatively expressed as fold increase compared to control brain expression, 12 and 24 h after tibia fracture in the CT-lip and the clodrolip-treated mice (n = 6 per group and per timing, two-way ANOVA, P = 0.06 for the treatment, P < 0.0001 for the time effect, P = 0.035 for interaction). C. Hippocampal mRNA expression of IL-1β relatively expressed as fold increase compared to control brain expression, 12 and 24 h after tibia fracture in the CT-lip and the clodrolip-treated mice (n = 6 per group and per timing, two-way ANOVA, P = 0.42 for the treatment effect, P < 0.0001 for the time effect, P = 0.66 for interaction). D. Hippocampal mRNA expression of MCP-1 relatively expressed as fold increase compared to control brain expression, 12 and 24 h after tibia fracture in the CT-lip and the clodrolip-treated mice (two-way ANOVA, P = 0.64 for the treatment, P = 0.0005 for the time effect, P = 0.67 for interaction). CT-lip = control liposome; IL = Interleukin; MCP-1 = monocyte chemoattractant protein-1; mRNA = messenger RNA; TNF = tumor necrosis factor. Boxes are means ± 95% confidence interval and data are presented with a logarithmic scale.