Table 1.

Boston Criteria for Cerebral Amyloid Angiopathy Diagnosis

1 Definite Cerebral Amyloid Angiopathy (CAA)

Full post-mortem examination demonstrating: lobar, cortical or corticosubcortical haemorrhage severe CAA with vasculopathy absence of other diagnostic lesion

2 Probable CAA with Supporting Pathology

Clinical data and pathological tissue (evacuated haematoma or cortical biopsy) demonstrating: lobar, cortical or corticosubcortical haemorrhage some degree of CAA in specimen absence of other diagnostic lesion

3 Probable CAA

Clinical data and MRI or CT demonstrating: multiple haemorrhages restricted to lobar, cortical or corticosubcortical regions (cerebellar haemorrhage allowed) age ≥55 years absence of other cause of haemorrhage*

4 Possible CAA

Clinical data and MRI or CT demonstrating: single lobar, cortical or corticosubcortical haemorrhage age ≥55 years absence of other cause of haemorrhage*

^*Other causes of intracerebral haemorrhage include: excessive warfarin dosing (international normalised ratio [INR] >3.0), antecedent head trauma or ischaemic stroke, central nervous system (CNS) tumour, vascular malformation, CNS vasculitis, blood dyscrasia, coagulopathy.

CT = computed tomography; MRI = magnetic resonance imaging.