Figure 1.

A: Diagram of the approach used to identify novel Izumo homologues. The domain architecture of the novel proteins is also indicated. B. Sequence alignment for each Izumo member in several species. The two letters indicate the species (Hs: Homo sapiens, Mm: Mus musculus, Rn: Ratus norvergicus, Bt: Bos taurus, Cl: Canislupass, Ss: Sus scrofa). The numbers correspond to the Gi accession number. Positions of conserved cysteines are indicated by the shaded background. Positions with mainly hydrophobic residues are in bold letters. Three proteins with manually curated sequences have their gi numbers underlined. Also underlined are the regions that are absent from these sequences but are retrieved from tblastn searches or gene prediction results.