Table 2.
Monoamine content in the various brain regions of toxic milk and control mice
| Brain region | Age (months) | DA (pg/mg tissue), mean ± SD | NA (pg/mg tissue), mean ± SD | 5-HT (pg/mg tissue), mean ± SD | |||
|---|---|---|---|---|---|---|---|
| Control | Toxic milk | Control | Toxic milk | Control | Toxic milk | ||
| Cerebral cortex | 2 | 25.9 ± 33.2 | 65.5 ± 25.3 | 364.5 ± 43.2 | 376.7 ± 87.9 | 294.7 ± 39.9 | 342.6 ± 52.3 |
| 12 | 201.7 ± 79.1 | 236.9 ± 85.9 | 315.4 ± 33.3 | 303.2 ± 46.7 | 401.3 ± 130.4 | 544.6 ± 127.5 (p < 0.02) | |
| Striatum | 2 | 11,465.9 ± 2,166.5 | 10,172.9 ± 1,352.7 | 69.6 ± 33.6 | 122.5 ± 51.6 | 423.1 ± 51.9 | 451.1 ± 37.3 |
| 12 | 12,639.1 ± 1,820.9 | 10,171.8 ± 1,125.8 (p < 0.006) | 81.3 ± 32.9 | 146.6 ± 37.6 | 290 ± 63.2 | 411 ± 110.9 (p < 0.007) | |
| Hippocamp | 2 | 18.5 ± 19.4 | 28.3 ± 36.9 | 285.1 ± 34.30 | 319.3 ± 92.8 | 208.9 ± 47.3 | 245.4 ± 26.1 |
| 12 | 81.9 ± 39.9 | 83.9 ± 42.3 | 332.4 ± 58.0 | 349.2 ± 56.0 | 432.8 ± 103.1 | 598.2 ± 229.3 (p < 0.02) | |
| Cerebellum | 2 | 12.9 ± 20.7 | 18.51 ± 3.9 | 218.3 ± 40.6 | 176.1 ± 46.2 | 46.5 ± 40.7 | 65.5 ± 21.4 |
| 12 | 31.55 ± 23.3 | 36.5 ± 22.4 | 164.1 ± 56.40 | 146.0 ± 47.2 | 145.6 ± 42.6 | 213.3 ± 75.4 (p < 0.04) | |
n = 8–10/group, p value is given for significant differences between genotypes in mice of the same age