Table 2.
Common variants associated with the QTc duration
| Locus | SNP | MAF | Location | Nearest gene | Function | QTc effect |
|---|---|---|---|---|---|---|
| 1q | rs12143842 | 0.16 | Intergenic | NOS1AP | Nitric oxide synthase 1 adaptor protein | ↑ |
| rs2880058 | 0.26 | Intergenic | ↑ | |||
| rs10494366 | 0.33 | Intron | ↓ | |||
| rs12029454 | 0.11 | Intron | ↑ | |||
| rs16857031 | 0.15 | Intron | ↑ | |||
| rs4657178 | 0.18 | Intron | ↑ | |||
| 1q | rs10919071 | 0.11 | Intron | ATP1B1 | β-subunit Na+/K+ ATPase | ↑ |
| 1p | rs846111 | 0.26 | 3′UTR | RNF207 | Ring finger protein | ↑ |
| 3p | rs11129795 | 0.34 | Intergenic | SCN5A | α-subunit INa channel (Nav1.5) | ↓ |
| rs12053903 | 0.29 | Intron | ↓ | |||
| 6q | rs12210810 | 0.08 | Intergenic | C6orf204 | Phosphorylation | ↓ |
| rs11970286 | 0.47 | Intergenic | ↑ | |||
| 7q | rs2968863 | 0.26 | Intergenic | KCNH2 | α-subunit IKr channel (Kv11.1) | ↓ |
| rs4725982 | 0.18 | Intergenic | ↑ | |||
| rs1805123 | 0.24 | Exon (K897T) | ↑↓ | |||
| 11p | rs12296050 | 0.23 | Intron | KCNQ1 | α-subunit IKs channel (Kv7.1) | ↑ |
| rs12576239 | 0.16 | Intron | ↑ | |||
| rs2074238 | 0.08 | Intron | ↓ | |||
| 12q | rs3825214 | 0.22 | Intron | TBX5 | Transcription | ↑ |
| 13q | rs2478333 | 0.35 | Intergenic | SUCLA2 | Mitochondrial enzyme | ↑ |
| 16p | rs8049607 | 0.49 | Intergenic | LITAF | Tumour necrosis factor | ↑ |
| 16q | rs37062 | 0.27 | Intron | CNOT1 | RNA transcription | ↓ |
| 17q | rs17779747 | 0.32 | Intergenic | KCNJ2 | α-subunit IK1 channel (Kir2) | ↓ |
| 17q | rs2074518 | 0.49 | Intron | LIG3 | DNA ligase III | ↓ |
| 21q | rs1805128 | 0.03 | Exon (D85N) | KCNE1 | β-subunit IKs channel (minK) | ↑ |
SNP, single nucleotide polymorphism; MAF, minor allele frequency; ↑, QTc prolongation; ↓, QTc shortening.