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. 2013 Jul 8;591(Pt 17):4167–4188. doi: 10.1113/jphysiol.2013.254938

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© 2013 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

© 2013 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A, 3-D plots of λ′ restitution curves against the BCL in the Scn5a^+/− RV epicardium and Scn5a^+/− RV epicardium treated with flecainide, showing the BCL_crit(λ) (circled) corresponding to the λ′_0crit value (arrowed). BCL_crit(λ) was markedly increased by flecainide in the Scn5a^+/− RV epicardium despite similar λ′_0crit values. This was due to changes in the BCD′ shown in box and whiskers plots (B) at 8 Hz (open plots) and 13.5 Hz (filled plots) pacing in the RV. Horizontal lines indicate the Mdn, boxes the IQR, and whiskers show the range. *Significant differences, P < 0.05; continuous lines show comparisons between 8 Hz pacing, and dashed lines show comparisons between 13.5 Hz pacing.