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. 2013 Jul 8;591(Pt 17):4167–4188. doi: 10.1113/jphysiol.2013.254938

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© 2013 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

© 2013 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Typical plots of the magnitude of λ′ alternans, mag_λ(alt) against λ′₀ in WT (open symbols; black lines) and Scn5a^+/− (filled symbols; grey lines), RV epicardium (A), and RV endocardium (B), before (circles; continuous line) and following addition of either flecainide (squares; dashed lines) or quinidine (triangles; dotted lines). Data represent the Mdn value of λ′_0crit(alt) as all curves progress together with common negative gradients.