Figure 6. Effect of combined I_Kr+I_K1 and I_Kr+I_Ks inhibition in human and dog ventricular muscle preparations (endocardial impalements).

A, representative APs at baseline (circle), following exposure to 10 μmol l⁻¹ BaCl₂ (triangle), 50 nmol l⁻¹ dofetilide (diamond), and combined 10 μmol l⁻¹ BaCl₂+ 50 nmol l⁻¹ dofetilide (rectangle) in human (top traces) and dog (bottom traces) ventricular muscle. Brackets show average differences between conditions indicated. B, representative APs at baseline (circle), following exposure to 1 μmol l⁻¹ HMR-1566 (triangle), 50 nmol l⁻¹ dofetilide (diamond), and combined 1 μmol l⁻¹ HMR-1566 + 50 nmol l⁻¹ dofetilide (rectangle) in human (top traces) and dog (bottom traces) ventricular muscle. Brackets show average differences between conditions indicated.