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. 2013 Jul 22;591(Pt 17):4189–4206. doi: 10.1113/jphysiol.2013.261198

Figure 10. Simulations of effect of combined IK+IK1 and IKr+IKs inhibition on human and dog ventricular muscle APs by applying the O’Hara dynamic (ORd) canine ventricular AP model.

Figure 10

A, simulated human APs at control, following IK1 block (70% reduction), IKr block (50% reduction), and combined IK1+IKr block. B, corresponding data for dog IK1+IKr block. C, simulated human APs at control, following IKs block (50% reduction), IKr block (50% reduction), and combined IKs+IKr block. D, corresponding data for dog IKs+IKr block.