Table 1.

Review of AF-induced remodelling data and model parameters

Process	Experimental observation	AF-1	AF-2	AF-3	AF-4
ICaL	−70%+ kinetic change (Bosch et al. 1999) −63% (van Wagoner et al. 1999) −72% (Skasa et al. 2001) −65% (Workman et al. 2001) −50%, +4 mV shift (Christ et al. 2004) −33% mRNA expression (Oh et al. 2010)	−70%τac,inac+60%	−65%	−63%	−70%
IKur	−49% (van Wagoner et al. 1997) −55% (Brandt et al. 2000) −55% RA (Caballero et al. 2010) −45% LA (Caballero et al. 2010) −50% (Christ et al. 2004) No change (Bosch et al. 1999) No change (Grammer et al. 2000) No change (Workman et al. 2001)	—	—	−49%	−50%
Ito	−66% (van Wagoner et al. 1997) −70%+ 16 mV shift (Bosch et al. 1999) −44% (Brandt et al. 2000) −65% (Workman et al. 2001) −50% RA (Caballero et al. 2010) −75% LA (Caballero et al. 2010) −80% (Grammer et al. 2000)	−70%+16 mV shift	−65%	−66%	−65%
IK1	+106% (van Wagoner et al. 1997) +100% (Bosch et al. 1999) +137% (Dobrev et al. 2001) +73% (Dobrev et al. 2002) +75% (Workman et al. 2001)	+100%	+75%	+106%	+100%
IKs	+100% LA (Caballero et al. 2010) > + 100% RA (Caballero et al. 2010) −30% mRNA (Lai et al. 1999) +56% mRNA (Brundel et al. 2001b)	—	—	—	+100%
INaCa	+43%± 14% (Neef et al. 2010) +67% (Schotten et al. 2002) +201% protein (El-Armouche et al. 2006) Increase (Voigt et al. 2012)	—	—	—	+55%
IKr	−27% mRNA (Lai et al. 1999) −34% mRNA (Brundel et al. 2001b) −30% mRNA expression (Oh et al. 2010) No change – mRNA (Brundel et al. 2001a)	—	—	—	No change
SERCA	Increased SR uptake (Shanmugam et al. 2011)	—	—	—	+50%
RyR	Open probability increased 4-fold (Voigt et al. 2012) Increased release (Hove-Madsen et al. 2004)	—	—	—	+300%
SR Ca2+ leak	Increased (Voigt et al. 2012)	—	—	—	+25%