Table 4. Gene promoter methylation status by HGPIN and PSA.
| Methylated Gene (No. pairs) | % HGPIN | Mean ± SD PSA (ng/ml) | ||
|---|---|---|---|---|
|
|
|
|||
| Pos/Neg Methylation | p Value | Pos/Neg Methylation | p Value | |
| Overall: | ||||
| MGMT (753) | 6.9/9.0 | 0.5 | 6.8 ± 5.3/6.9 ± 6.9 | 0.9 |
| APC (826) | 10.3/7.8 | 0.4 | 6.8 ± 5.6/6.8 ± 6.9 | 0.9 |
| RARB (806) | 14.0/5.3 | <0.0001 | 7.3 ± 7.2/6.7 ± 6.3 | 0.3 |
| CCND2 (772) | 8.6/8.0 | 0.9 | 6.5 ± 5.0/6.8 ± 6.5 | 0.7 |
| RASSF1 (790) | 9.8/8.5 | 0.6 | 6.2 ± 5.2/7.0 ± 6.9 | 0.09 |
| Black: | ||||
| MGMT (300) | 3.9/9.1 | 0.7 | 7.6 ± 6.0/7.5 ± 7.7 | 0.9 |
| APC (324) | 7.8/8.6 | >0.99 | 6.9 ± 4.8/7.8 ± 8.2 | 0.3 |
| RARB (322) | 13.1/4.2 | 0.005 | 8.2 ± 8.2/7.2 ± 6.7 | 0.3 |
| CCND2 (303) | 3.7/8.0 | 0.7 | 7.3 ± 5.4/7.3 ± 7.3 | >0.99 |
| RASSF1 (303) | 6.0/8.7 | 0.8 | 6.8 ± 5.8/7.9 ± 7.9 | 0.2 |
| White: | ||||
| MGMT (453) | 8.5/8.9 | >0.99 | 6.3 ± 4.8/6.4 ± 6.2 | 0.9 |
| APC (502) | 12.5/7.3 | 0.1 | 6.7 ± 6.2/6.3 ± 5.9 | 0.5 |
| RARB (484) | 14.8/6.0 | 0.0005 | 6.4 ± 6.0/6.4 ± 6.1 | 0.97 |
| CCND2 (469) | 11.6/8.0 | 0.4 | 6.1 ± 4.7/6.4 ± 5.9 | 0.7 |
| RASSF1 (487) | 11.5/8.3 | 0.4 | 6.0 ± 4.9/6.4 ± 6.0 | 0.4 |