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. 2013 Sep 20;8(9):e76790. doi: 10.1371/journal.pone.0076790

Figure 4. Inhibition of ERK1/2 by U0126 increased intestinal inflammation, permeability and injury in vivo.

Figure 4

Mice were pretreated with U0126 or vehicle and then subjected to one hour ischemia followed by 6 hours reperfusion in the intestine (n=5). The intestinal tissue was examined. A. MPO activity by a commercial Kit. B. Permeability by the ex-vivo isolated everted ileum sac method. C. Representative images by HE staining. D. Quantitative tissue damage by Park/Chiu scoring system. Sham-U=Sham-U0126, IR=I/R, IR-U=I/R-U0126.