Table 3. Buried Surface Area (BSA).
PDB ID | Complex | N-TIMP/MMP BSA (Å2) | N-TIMP/MMP ΔG (kcal/mol)† | C-TIMP/MMP BSA (Å2) | C-TIMP/MMP ΔG (kcal/mol)† |
4ILW | MMP-10cd/TIMP-2 | 1131.5/1137.2 | −11.7 | 127.7/122.8 | −2.7 |
3V96 | MMP-10cd/TIMP-1 | 892.1/793.5 | −12.0 | 405.5/415.5 | −4.1 |
1UEA | MMP-3cd/TIMP-1 | 1025.3/939.5 | −17.7 | 416.6/433.4 | −6.8 |
1BQQ | MT1-MMPcd/TIMP-2 | 1136.0/1049.2 | −15.6 | 547.0/627.2 | −3.0 |
2E2D | MMP-13cd/TIMP-2 | 949.6/850.1 | −14.2 | 356.4/342.8 | −2.0 |
ΔG refers to changes in solvation energy on complex formation.