Skip to main content
. 2013 Sep 20;8(9):e75875. doi: 10.1371/journal.pone.0075875

Figure 5. Kv7.1-Kv7.5 inhibitors, XE991 and linopiridine, increased spontaneous phasic contractions in guinea pig DSM isolated strips.

Figure 5

A) This original DSM tension recording illustrates that XE991 enhances spontaneous phasic contractions in isolated DSM strips in a concentration-dependent manner. B) Cumulative concentration-response curves for XE991 show increases in DSM spontaneous phasic contractions amplitude and muscle force (n=8, N=5). C) This original DSM tension recording exemplifies that linopiridine increases DSM spontaneous phasic contractions in a concentration-dependent manner. D) Cumulative concentration-response curves for linopiridine depict increases in DSM spontaneous phasic contractions amplitude and muscle force (n=7, N=5). Table 1 provides a summary of potency and maximum efficacy values. TTX (1 µM) was present throughout the experiments.