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. 2013 Sep 20;8(9):e75499. doi: 10.1371/journal.pone.0075499

Figure 4. Experimental localization of the active synaptic domain and determination of its chemical nature.

Figure 4

Excitatory and inhibitory neurotransmitter blockers were injected locally, one at a time, near the linear probe at the sites located in the spatial domains found after CSD analysis of virtual Schaffer LFPs (A). DNQX and bicuculline (BIC) were injected in the st. pyr./st. or (Experiments 1 and 3). or the st. rad. (Experiments 2 and 4). The plots illustrate the temporal envelopes of the activity of the Schaffer generator obtained following ICA of the LFP profiles before and after drug injection (inj). The insets show sample epochs of virtual Schaffer LFPs. Note that only the Glu-receptor blocker DNQX abolished the activity of this generator when applied in the st. rad. (Expt. 2). All experiments belong to the same animal. B shows the population data (mean ± s.e.m.; n is the number of animals): ***p<0.001, Student’s t-test.