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. 2013 Sep 20;8(9):e75091. doi: 10.1371/journal.pone.0075091

Figure 3. Serum NfL levels in the two reference groups (healthy controls, HC and control patients, CP) and neurological disease groups.

Figure 3

Patients with a Guillain-Barré syndrome (GBS) (79.4 pg/ml) or Amyotrophic lateral sclerosis (ALS) (95.4 pg/ml) had higher values compared with HC (3.3 pg/ml; p<0.0001, respectively) and CP (4.4 pg/ml, p<0.0001 and p=0.001). Significances for comparisons between patients with Alzheimer’s disease (AD) and HC (p<0.0001) and AD and CP (p=0.002) were lost after age corrections. The horizontal dotted line represents the upper reference range (cut-off value) of 26.6 pg/ml. Geometric mean and 95% CI are displayed. Dots represent individual samples. P-values are adjusted for age and corrected by Bonferroni method.