Fig. 6.

iPSC-Derived hepatocyte-like cells can rescue CCl₄-induced lethal fulminant hepatic failure. (A) Survival curves of NOD-SCID mice (n = 7 in each group) that received intrasplenic cell transplantation with 4.0 × 10⁷ iPSC-derived hepatocytes per kilogram body weight. (B) Appearance and histopathology of liver showed the organs with or without received cell transplantation (iPSC-derived hepatocytes or iPSCs) after administration of CCl₄ (Panels i and v = normal liver; Panels ii and vi = iPSC-derived hepatocytes transplanted after administration of CCl₄; Panels iii and vii = iPSCs transplanted after administration of CCl₄; Panels iv and viii = intrasplenic saline injection after administration of CCl₄). (C,D) Detection of human hepatocytes with anti-human HepPar1 and human albumin antibodies with immunohistochemistry. (Original magnification, ×200).