. Author manuscript; available in PMC: 2013 Sep 21.

Published in final edited form as: Hepatology. 2012 Mar 1;55(4):1193–1203. doi: 10.1002/hep.24790

Table 2.

Liver Function Tests of NOD-SCID Mice That Were Administered 0.35 mL/kg CCl₄ and Intrasplenic Transplantation of iPSC-Derived Hepatocyte Cells

	Serum Glutamyl Oxaloacetic Aminotransferase (IU/L)	Serum Glutamyl Pyruvic Aminotransferase (IU/L)	Albumin (g/dL)	Total Bilirubin (mg/dL)	Lactate Dehydrogenase (IU/L)
Normal NOD-SCID	60 ± 6.6	34 ± 5.8	2.5 ± 0.11	0.4 ± 0.08	336 ± 14.5
Post-CCl₄ day 1
Placebo	> 1000	> 1000	3.4 ± 0.22	1.7 ± 0.23	> 4000
iH-CT	> 1000	> 1000	3.4 ± 0.16	1.7 ± 0.11	> 4000
Post-CCl₄ day 3
Placebo	513 ± 29.6	536 ± 93.2	3.2 ± 0.17	1.6 ± 0.10	3738 ± 123.8
iH-CT	191 ± 57.2	128 ± 24.0	2.7 ± 0.19	0.6 ± 0.43	427 ± 31.8
Post-CCl₄ day 7
Placebo	681 ± 31.6	557 ± 54.3	3.2 ± 0.08	1.7 ± 0.17	3754 ± 89.5
iH-CT	71 ± 12.9	39 ± 10.2	2.6 ± 0.12	0.4 ± 0.08	467 ± 41.3
Post-CCl₄ day 14
Placebo	ND	ND	ND	ND	ND
iH-CT	70 ± 8.9	45 ± 8.2	2.6 ± 0.04	0.4 ± 0.13	407 ± 20.2
Post-CCl₄ day 21
Placebo	ND	ND	ND	ND	ND
iH-CT	70 ± 4.6	44 ± 6.3	2.6 ± 0.09	0.5 ± 0.06	451 ± 37.0
Post-CCl₄ day 28
Placebo	ND	ND	ND	ND	ND
iH-CT	76 ± 4.2	43 ± 7.6	2.6 ± 0.12	0.4 ± 0.09	435 ± 49.0

Abbreviations: iH-CT, iPSC-derived hepatocyte cell transplantation; ND, not done.