Fig. 1.

Heightened striatal dopamine release during gambling in Parkinson’s disease (PD) with pathological gambling (a) [35] and reduced activation of the orbitofrontal cortex (OFC) and rostral cingulate zone (RCZ) in pathological gambling after dopamine (DA) administration (b) [91•]. a Ventral striatal DA release (indexed by a reduction of [¹¹C]raclopride binding potential) during gambling as compared with that in a control task in PD patients with (top) and without (bottom) pathological gambling. b Differential effect of medication on brain activity in PD gamblers compared to controls. Gamblers showed a significant dopamine-induced reduction in the left lateral OFC (top) and right RCZ (bottom). (a With permission from: Steeves et al. [35]; b with permission from van Eimeren et al. [91•])