Table 5.
Additional top metabolism/antioxidant gene SNP – fruit, vegetable, fiber, and grain intake category interactions that are associated with pancreatic adenocarcinoma. These interactions are significant based on a P ≤ 0.008.
(Control %/Case %) | Odds Ratio (95% CI) | |||||||
---|---|---|---|---|---|---|---|---|
|
||||||||
Gene | Possible Influence | RS number | Nutrient | 0 | ≥ 1 | 0 | ≥ 1 | Interaction P |
UGT2B4 | intron | rs17671289 | Low dry beans and peas | 29.11/28.69 | 20.84/29.48 | 1.00 (ref) | 1.43 (0.965,2.106) | 0.0078 |
High dry beans and peas | 28.56/27.89 | 21.50/13.94 | 1.02 (0.690,1.492) | 0.634 (0.403,1.008) | ||||
CAT | intron | rs11032703 | Low total grains | 38.52/32.80 | 11.37/14.80 | 1.00 (ref) | 1.48 (0.932,2.356) | 0.0018 |
High total grains | 37.97/45.20 | 12.14/7.20 | 1.62 (1.147,2.283) | 0.75 (0.424,1.338) | ||||
3′downstream | rs475043 | Low total grains | 17.31/9.96 | 32.64/37.85 | 1.00 (ref) | 1.90 (1.155,3.136) | 0.0033 | |
High total grains | 16.65/20.72 | 33.41/31.47 | 2.45 (1.418,4.227) | 1.77 (1.065,2.929) | ||||
GSTP1 | missense | rs1138272 | Low total grains | 41.46/42.63 | 8.49/5.18 | 1.00 (ref) | 0.49 (0.253,0.964) | 0.003 |
High total grains | 42.45/40.24 | 7.61/11.95 | 1.03 (0.742,1.429) | 1.80 (1.086,2.975) | ||||
Low non-whole grains | 41.46/39.04 | 8.49/4.38 | 1.00 (ref) | 0.49 (0.240,1.002) | 0.0072 | |||
High non-whole grains | 42.45/43.82 | 7.61/12.75 | 1.28 (0.918,1.783) | 2.05 (1.241,3.391) | ||||
MT1E | 5′upstream | rs7403881 | Low total fruits | 13.02/22.31 | 37.09/38.25 | 1.00 (ref) | 0.63 (0.419,0.946) | 0.0011 |
High total fruits | 13.47/5.18 | 36.42/34.26 | 0.24 (0.124,0.475) | 0.53 (0.349,0.809) | ||||
Low other fruits | 11.48/21.12 | 38.63/41.83 | 1.00 (ref) | 0.61 (0.403,0.920) | 0.0018 | |||
High other fruits | 15.01/6.37 | 34.88/30.68 | 0.27 (0.142,0.505) | 0.51 (0.329,0.787) | ||||
GAA | 5′upstream | rs3816257 | Low other starches | 19.51/15.20 | 30.54/43.20 | 1.00 (ref) | 1.88 (1.222,2.883) | 0.0022 |
High other starches | 18.63/18.40 | 31.31/23.20 | 1.40 (0.854,2.286) | 1.00 (0.630,1.593) | ||||
synonymous | rs1042396 | Low orange/grapefruit juice | 25.91/29.48 | 23.93/25.50 | 1.00 (ref) | 0.97 (0.654,1.446) | 0.0036 | |
High orange/grapefruit juice | 26.57/14.34 | 23.59/30.68 | 0.43 (0.275,0.678) | 1.02 (0.697,1.506) | ||||
3′UTR | rs2304851 | Low orange/grapefruit juice | 22.38/20.72 | 27.45/34.26 | 1.00 (ref) | 1.43 (0.954,2.146) | 0.0043 | |
High orange/grapefruit juice | 21.17/24.30 | 29.00/20.72 | 1.15 (0.742,1.786) | 0.70 (0.446,1.088) |