Table 5.

Additional top metabolism/antioxidant gene SNP – fruit, vegetable, fiber, and grain intake category interactions that are associated with pancreatic adenocarcinoma. These interactions are significant based on a P ≤ 0.008.

				(Control %/Case %)		Odds Ratio (95% CI)
Gene	Possible Influence	RS number	Nutrient	0	≥ 1	0	≥ 1	Interaction P
UGT2B4	intron	rs17671289	Low dry beans and peas	29.11/28.69	20.84/29.48	1.00 (ref)	1.43 (0.965,2.106)	0.0078
			High dry beans and peas	28.56/27.89	21.50/13.94	1.02 (0.690,1.492)	0.634 (0.403,1.008)
CAT	intron	rs11032703	Low total grains	38.52/32.80	11.37/14.80	1.00 (ref)	1.48 (0.932,2.356)	0.0018
			High total grains	37.97/45.20	12.14/7.20	1.62 (1.147,2.283)	0.75 (0.424,1.338)
	3′downstream	rs475043	Low total grains	17.31/9.96	32.64/37.85	1.00 (ref)	1.90 (1.155,3.136)	0.0033
			High total grains	16.65/20.72	33.41/31.47	2.45 (1.418,4.227)	1.77 (1.065,2.929)
GSTP1	missense	rs1138272	Low total grains	41.46/42.63	8.49/5.18	1.00 (ref)	0.49 (0.253,0.964)	0.003
			High total grains	42.45/40.24	7.61/11.95	1.03 (0.742,1.429)	1.80 (1.086,2.975)
			Low non-whole grains	41.46/39.04	8.49/4.38	1.00 (ref)	0.49 (0.240,1.002)	0.0072
			High non-whole grains	42.45/43.82	7.61/12.75	1.28 (0.918,1.783)	2.05 (1.241,3.391)
MT1E	5′upstream	rs7403881	Low total fruits	13.02/22.31	37.09/38.25	1.00 (ref)	0.63 (0.419,0.946)	0.0011
			High total fruits	13.47/5.18	36.42/34.26	0.24 (0.124,0.475)	0.53 (0.349,0.809)
			Low other fruits	11.48/21.12	38.63/41.83	1.00 (ref)	0.61 (0.403,0.920)	0.0018
			High other fruits	15.01/6.37	34.88/30.68	0.27 (0.142,0.505)	0.51 (0.329,0.787)
GAA	5′upstream	rs3816257	Low other starches	19.51/15.20	30.54/43.20	1.00 (ref)	1.88 (1.222,2.883)	0.0022
			High other starches	18.63/18.40	31.31/23.20	1.40 (0.854,2.286)	1.00 (0.630,1.593)
	synonymous	rs1042396	Low orange/grapefruit juice	25.91/29.48	23.93/25.50	1.00 (ref)	0.97 (0.654,1.446)	0.0036
			High orange/grapefruit juice	26.57/14.34	23.59/30.68	0.43 (0.275,0.678)	1.02 (0.697,1.506)
	3′UTR	rs2304851	Low orange/grapefruit juice	22.38/20.72	27.45/34.26	1.00 (ref)	1.43 (0.954,2.146)	0.0043
			High orange/grapefruit juice	21.17/24.30	29.00/20.72	1.15 (0.742,1.786)	0.70 (0.446,1.088)