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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Pancreas. 2013 Oct;42(7):1043–1053. doi: 10.1097/MPA.0b013e3182968e00

Table 5.

Additional top metabolism/antioxidant gene SNP – fruit, vegetable, fiber, and grain intake category interactions that are associated with pancreatic adenocarcinoma. These interactions are significant based on a P ≤ 0.008.

(Control %/Case %) Odds Ratio (95% CI)

Gene Possible Influence RS number Nutrient 0 ≥ 1 0 ≥ 1 Interaction P
UGT2B4 intron rs17671289 Low dry beans and peas 29.11/28.69 20.84/29.48 1.00 (ref) 1.43 (0.965,2.106) 0.0078
High dry beans and peas 28.56/27.89 21.50/13.94 1.02 (0.690,1.492) 0.634 (0.403,1.008)
CAT intron rs11032703 Low total grains 38.52/32.80 11.37/14.80 1.00 (ref) 1.48 (0.932,2.356) 0.0018
High total grains 37.97/45.20 12.14/7.20 1.62 (1.147,2.283) 0.75 (0.424,1.338)
3′downstream rs475043 Low total grains 17.31/9.96 32.64/37.85 1.00 (ref) 1.90 (1.155,3.136) 0.0033
High total grains 16.65/20.72 33.41/31.47 2.45 (1.418,4.227) 1.77 (1.065,2.929)
GSTP1 missense rs1138272 Low total grains 41.46/42.63 8.49/5.18 1.00 (ref) 0.49 (0.253,0.964) 0.003
High total grains 42.45/40.24 7.61/11.95 1.03 (0.742,1.429) 1.80 (1.086,2.975)
Low non-whole grains 41.46/39.04 8.49/4.38 1.00 (ref) 0.49 (0.240,1.002) 0.0072
High non-whole grains 42.45/43.82 7.61/12.75 1.28 (0.918,1.783) 2.05 (1.241,3.391)
MT1E 5′upstream rs7403881 Low total fruits 13.02/22.31 37.09/38.25 1.00 (ref) 0.63 (0.419,0.946) 0.0011
High total fruits 13.47/5.18 36.42/34.26 0.24 (0.124,0.475) 0.53 (0.349,0.809)
Low other fruits 11.48/21.12 38.63/41.83 1.00 (ref) 0.61 (0.403,0.920) 0.0018
High other fruits 15.01/6.37 34.88/30.68 0.27 (0.142,0.505) 0.51 (0.329,0.787)
GAA 5′upstream rs3816257 Low other starches 19.51/15.20 30.54/43.20 1.00 (ref) 1.88 (1.222,2.883) 0.0022
High other starches 18.63/18.40 31.31/23.20 1.40 (0.854,2.286) 1.00 (0.630,1.593)
synonymous rs1042396 Low orange/grapefruit juice 25.91/29.48 23.93/25.50 1.00 (ref) 0.97 (0.654,1.446) 0.0036
High orange/grapefruit juice 26.57/14.34 23.59/30.68 0.43 (0.275,0.678) 1.02 (0.697,1.506)
3′UTR rs2304851 Low orange/grapefruit juice 22.38/20.72 27.45/34.26 1.00 (ref) 1.43 (0.954,2.146) 0.0043
High orange/grapefruit juice 21.17/24.30 29.00/20.72 1.15 (0.742,1.786) 0.70 (0.446,1.088)
HHS Vulnerability Disclosure