Table 3.

Univariate and multivariate analyses of overall survival with patient characteristics and plasma levels of miR-155 levels in group C patients

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P
FISH (17p deletion vs others)*	9.86 (1.97, 49.45)	.005
Rai (low [0, 1, 2] vs high [3, 4])	0.85 (0.36, 1.99)	.7	1.18 (0.47, 2.94)	.14
IgHV (unmutated vs mutated)	2.58 (0.87, 7.62)	.086	2.3 (0.77, 6.87)	.73
ZAP70 (positive [>20%] vs negative [<20%])	1.15 (0.5, 2.67)	.74
B2M (low [≤3.3 mg/L median] vs high (> 3.3 mg/L median])	0.98 (0.44, 2.19)	.97
Fold difference miR-155†	73.57 (2.77, 1951.97)	.01	52.43 (1.58, 1739.65)	.027

CI, confidence interval; HR, hazard ratio.

^*Others = 11q deletion; trisomy 12; 13q deletion; no abnormalities.

^†Fold difference miR-155 was measured using the 2^−ΔCt method vs miR-16 as the normalizer.