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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Contemp Clin Trials. 2013 May 8;36(2):10.1016/j.cct.2013.05.001. doi: 10.1016/j.cct.2013.05.001

Figure 3. Direct Assignment option Design with 2 planned interim analyses (IA), with an option for direct assignment at each analysis for one biomarker defined subgroup.

Figure 3

Fut: futility; eff: efficacy; dir: direct; rand: randomize

c1, c2, c3, c4 (=c2), c5 (=c7), c6, c7: O’Brien-Fleming stopping boundaries