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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Mol Med (Berl). 2013 May 18;91(10):1143–1154. doi: 10.1007/s00109-013-1051-z

Figure 4.

Figure 4

All mice were infected with mouse polyoma virus on day 0. On day 28, mice were challenged with either wild type vaccinia virus (VV-WT) or a genetically modified vaccinia virus expressing the polyoma amino acid sequence LT359-368 (VV-LT). Four days after the vaccinia infection, the mice were sacrificed and the titer of vaccinia virus in the ovaries of each mouse was measured by a plaque assay. ACE 10/10 mice are not intrinsically resistant to WT vaccinia virus. However, once immunized with polyoma virus, the ACE 10/10 mice were substantially more resistant to VV-LT vaccinia virus that expressed the major MHC class I epitope of polyoma. The figure shows data from individual mice, as well as the group means and S.E.M.