Figure 1.
Increased protein expression of nerve growth factor (NGF) in urinary bladder (A) and lumbosacral dorsal root ganglia (DRG) (B) in mice with chronic urothelial overexpression of NGF (NGF-OE). NGF protein content was significantly (p ≤ 0.001) increased in urinary bladder of NGF-OE compared to littermate wildtype (WT) mice (A). NGF protein content was significantly (p ≤ 0.001) increased in lumbosacral (L1, L2, L5-S1) DRG of NGF-OE compared to WT mice (B). No change in NGF protein content was observed in L5 DRG of NGF-OE mice compared to WT mice. Increased NGF expression was similar in L1, L2, L6 and S1 DRG from NGF-OE mice. Samples size are n of 7 – 9; *, p ≤ 0.001 versus WT.