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. Author manuscript; available in PMC: 2014 Jul 19.
Published in final edited form as: Org Lett. 2013 Jul 9;15(14):3774–3777. doi: 10.1021/ol401723h

Figure 1.

Figure 1

α-pyrones 79 biosynthesized by CazF in the presence of (i) malonyl-CoA and SAM 1 or (ii) malonyl-CoA and ProSeAM 2. HPLC traces are shown in the same scale at λ= 280 nm. Domain organization of CazF consists of a ketosynthase (KS), malonyl-CoA:ACP acyltransferase (MAT), dehydratase (DH), methyltransferase (MT), enoyl reductase (ER) ketoreductase (KR) and acyl carrier protein (ACP).