Figure 1.
α-pyrones 7–9 biosynthesized by CazF in the presence of (i) malonyl-CoA and SAM 1 or (ii) malonyl-CoA and ProSeAM 2. HPLC traces are shown in the same scale at λ= 280 nm. Domain organization of CazF consists of a ketosynthase (KS), malonyl-CoA:ACP acyltransferase (MAT), dehydratase (DH), methyltransferase (MT), enoyl reductase (ER) ketoreductase (KR) and acyl carrier protein (ACP).
