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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Hepatol. 2013 May 23;59(4):805–813. doi: 10.1016/j.jhep.2013.05.023

Fig 2. ASMase is required for alcohol induced mChol trafficking and mGSH depletion.

Fig 2

Confocal imaging of hepatocytes to detect colocalization of cholesterol (filipin) with mitochondria (cytochrome c) (A, B). Liver samples were processed for StARD1, Mln64 and caveolin-1 expression (C-E) and isolated mitochondria were analyzed for cholesterol (F) and GSH (G) levels. Results are the mean ± SD (6 mice per group). *p<0.01 vs. WT mice fed control diet, #p<0.01 vs. WT mice fed ethanol diet. StARD1 (H) and SREBP-2 (I) from HepG2 cells challenged with tunicamycin (Tm) with or without TUDCA. Results are the mean ± SD (n=4). *p<0.01 vs. control cells, #p<0.01 vs. cells incubated with Tm.