Figure 6.
Expression pattern of MUC4/8G7 and MUC4/1G8 in gastric-type IPMN-H (A-C) and invasive tubular adenocarcinoma derived from gastric-type IPMN (D-F). In the gastric-type IPMN, MUC4/8G7 was expressed mainly in the cytoplasm of the neoplastic cells showing high-grade dysplasia (B, left side), whereas it was not expressed in the neoplastic cells showing low-grade dysplasia (B, right side). In contrast, MUC4/1G8 was expressed mainly at the cell apexes of the neoplastic cells showing high-grade dysplasia (C, left side), whereas it was not expressed in the neoplastic cells showing low-grade dysplasia (C, right side). In the invasive tubular adenocarcinoma derived from gastric-type IPMN (D), MUC4/8G7 was expressed mainly in the cytoplasm of the neoplastic cells (E), whereas MUC4/1G8 was expressed mainly at the cell apexes (F). HE (A and D, Original magnification x200), MUC4/8G7 (B and E x200) and MUC4/1G8 (C and F x200).