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Genes independent of the HIF-1 pathway. This figure shows life spans of Caenorhabditis elegans cultured at 20°C on UV-killed OP50 bacteria in both normoxia (21% O2) and hypoxia (0.5% O2) throughout adulthood. (A) sir-2.1, (B) aak-2, and (C) cep-1 worms in hypoxia have increased longevity (median life-span increases of 8.3%, p value 9.6E-6; 9.5%, p value 4.6E-8; and 3.7%, p value 5.1E-3, respectively). Composite of all trials are shown. Significance: *p < .01, **p < .001.
