. Author manuscript; available in PMC: 2013 Sep 22.

Published in final edited form as: Anesth Analg. 2009 Dec;109(6):1943–1948. doi: 10.1213/ANE.0b013e3181beeb3b

Table 1.

Effect of Treatments on Physiologic Variables

	NTG		NTG + NIMO		NIMO
Dependent variables	Baseline	5-h average	Baseline	5-h average	Baseline	5-h average
MAP (mm Hg)	85.9 ± 3.8	31.6 ± 0.8^*	86.2 ± 3.7	32.6 ± 0.2^*	88.1 ± 3.8	80.0 ± 2.9
% change from baseline		36.8 ± 0.9^*		37.8 ± 0.9^*		90.7 ± 3.3
PInd, % change from baseline	100	30.4 ± 5.0^*	100	31.6 ± 0.8^*	100	89.8 ± 5.3
PbtO₂ (mm Hg)	51.7 ± 4.5	33.8 ± 5.2	38.6 ± 6.1	25.4 ± 2.0	24.3 ± 4.8	23.2 ± 2.3
% change from baseline		65.3 ± 9.1		65.9 ± 5.3		95.2 ± 9.4
O₂ saturation	99.0 ± 0.1	98.2 ± 0.1	98.9 ± 0.2	97.8 ± 0.7	98.5 ± 0.3	98.7 ± 0.1
HR (bpm)	463.7 ± 12.3	465.8 ± 7.2	424.0 ± 10.3	360.8 ± 17.9	431.7 ± 10.2	398.0 ± 8.5

All data are presented as mean ± sem. Change in mean arterial blood pressure (MAP) and perfusion index (PInd) is significantly larger in animals treated with nitroglycerin (NTG) or NTG + nimodipine (NIMO) than in the NIMO group (Mann-Whitney test).

PbtO₂ = brain tissue oxygenation; HR = heart rate.

Statistical significance (P < 0.05).