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Mean (SD) steady-state GS-9450 concentration-versus-time profiles. GS-9450 was quantifiable over the dosing interval for all treatment groups. Examination of the mean and median GS-9450 trough values and mean predose and 24-hour post-dose concentrations achieved during serial pharmacokinetic assessment for each group indicated that steady state had been reached by 2–4 weeks of daily dosing.
