TABLE 1.
IC50 of β-lactone inhibitor compounds with P. falciparum NF54 strain
A cytotoxicity test was performed on L6 rat myoblast cells. All results are expressed as ng/ml. —, no data.
| Compound | Compounds added at T0 and reading taken at 24, 48, and 72 h |
Fresh compound added every 12 h; 72-ha IC50 NF54 | Compound added at T0; 72-h IC50 cytotoxicity | ||
|---|---|---|---|---|---|
| 24-h IC50 NF54 | 48-h IC50 NF54 | 72-h IC50 NF54 | |||
| 3 | 22,853 | 8,724 | 17,652 | 11,616 | 3,555 |
| 1 | 8,992 | 1,435 | 3,231 | 1,017 | 4,820 |
| 2 | 8,140 | 1,577 | 2,259 | 1,746 | 3,175 |
| Artesunate | 1.9 | 1.6 | 1.7 | 1.2 | — |
| Chloroquine | 5.1 | 4.1 | 4.3 | — | — |
| Podophyllotoxin | — | — | — | — | 6 |
a One reading taken at 72 h.