FIGURE 3.

The TNFα-Adalimumab Fab interface. A, surface representations of the Adalimumab Fab (left) and the TNFα-Adalimumab Fab complex (right) and ribbon diagrams corresponding to the surfaces shown above with the same color scheme. The light chain and heavy chains of the Adalimumab Fab are colored yellow and red, respectively, whereas TNFα molecules are colored green, blue, and cyan. Contact surfaces are highlighted in blue on Adalimumab and red on TNFα. B, stereo view of the detailed TNFα-Adalimumab Fab interface. The residues that are involved in the intermolecular interaction are shown as colored sticks with the same scheme as the surface representation above; the Adalimumab Fab and TNFα molecules are presented as ribbon diagrams. Dashed lines denote hydrogen bonds.