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Bile acid-induced cell injury is dependent on cADPR. Acinar cells were pretreated with the cADPR inhibitor 8-Br-cADPR (30 μm) for 30 min prior to a 2-h incubation with TLCS (500 μm). Cell injury was measured by percent LDH release (A) and propidium iodide uptake (B) (n = 3). * and #, p < 0.05 compared with the control and TLCS alone, respectively.
