Inhibition of TLQP-21 activity by SB290157.
A, calcium measurement after ATP priming of CHO-K1 cells. Shown is the concentration inhibition curve of SB290157 for 1 μm rat TLQP-21 (●) and 1 μm positive control (▴; ATP, bradykinin, carbachol, sphingosine 1-phosphate, and lysophosphatidic acid 18:0). B, concentration inhibition curve of SB290157 for 1 μm rat TLQP-21 generated by Fluo-4-based calcium measurement after ATP priming of O-342 cells. All data are represented as signal − base line/base-line signal (ΔF/F) ± S.D.