TABLE 3.
Buried surface area (Å2) of the A- and B-subunits at the A- and B-subunit interface
| Family 1 SubAB | Family 2 |
Family 3 Ptx (PDB code: 1PRT) | Family 4 |
||||
|---|---|---|---|---|---|---|---|
| LT-I (PDB code: 1LTI) | LT-IIb (PDB code: 1TII) | Ctx (PDB code: 1S5E) | Stx (PDB code: 1R4P) | Stx2 (PDB code: 1DM0) | |||
| Protomer Ba | 237 (247)b | 395 (389) | 235 (237) | 261 (240) | 260 (283) | 217 (224) | 375 (358) |
| Protomer C | 548 (586) | 619 (656) | 376 (367) | 445 (437) | 371 (385) | 331 (338) | 496 (486) |
| Protomer D | 284 (316) | 318 (350) | 393 (448) | 481 (506) | 422 (461) | 206 (226) | 566 (571) |
| Protomer E | 427 (399) | 295 (297) | 320 (340) | 473 (497) | 655 (618) | 287 (295) | 537 (590) |
| Protomer F | 365 (402) | 624 (609) | 183 (196) | 302 (327) | 664 (627) | 277 (278) | 475 (457) |
| Total | 1861 [48.5%]c (1950) | 2251 [49.4%] (2301) | 1507 [48.7%] (1588) | 1962 [49.4%] (2007) | 2372 [50%] (2374) | 1318 [49.2%] (1361) | 2449 [49.8%] (2462) |
a The protomer chain name refers only to SubB.
b Values in parentheses are for the corresponding A-subunit buried surface area at the holotoxin interface. The buried surface area was calculated using the Protein Interfaces, Surfaces and Assemblies Service (PISA) at European Bioinformatics Institute (16).
c Relative BSA contribution (%) of the B-subunits to the SubA/SubB interface.