Figure 2.

Morris water maze results for all mice prior to sleep restriction (pre-SR) and after the 6 week sleep restriction period for control (post-SR CTL), large cage control (post-SR LCC) and sleep restricted mice (post-SR SR). The latency time to reach the hidden platform decreased over time for mice tested prior to the sleep restriction period (A). Mean swim speed was not significantly different between groups (B). At both the 4 and 24 hour probe test (C&D), mice tested prior to the sleep restriction period spent a significantly greater amount of time in the target quadrant (p<0.005) whereas after the 6 week sleep restriction period no groups, including control, displayed significant preference for the target quadrant, indicating a lack of short term memory retention.