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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Immunol. 2013 Jul 22;191(5):2258–2265. doi: 10.4049/jimmunol.1300585

Figure 5. The effects of anti-IL-10R mAb are maintained for at least 3 weeks after terminating treatment.

Figure 5

Latently infected mice (35 dpi) were treated with PBS or anti-IL-10R mAb for 3 weeks and were then rested for an additional 3 weeks. After rest, TG cells were stained for CD8α, granzyme B (GrzB), and with gB498-505 tetramers (gB-Tet), and analyzed by flow cytometry. (A) Bars represent the cumulative mean ± SEM number of gB-Tet+ and gB-Tet-CD8+ T cells per TG (2 experiments, n = 9 – 16 mice). (B) Bars represent the cumulative mean ± SEM number of gB-Tet+ and gB-Tet-cells that express GrzB(3 experiments, n=16–20 mice). (C) Representative dot plots gated on CD8 showing GrzB. Statistical significance was determined by an unpaired Student’s T tests. *p ≤ 0.05, ** p ≤ 0.005, *** p ≤ 0.0005.