Table 3.
Means, standard deviations, Cox regression coefficients, and corcordance estimates for CDR-SB slope (yr−1), the proposed surrogate measure in the mid-risk stratum.
| Population | PPG Cohort | NACC-UDS cohort | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
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| ||||||||||
| Mean±SD | Cox regression | Concordance | Mean±SD | Cox regression | Concordance | |||||
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| Beta (95% CI) | P value | Abs.1 | Change2 (90% CI3) | Beta (95% CI) | P value | Abs.1 | Change2 (90% CI3) | |||
| All non-demented | 0.169±0.299 | 3.31 (2.08,4.53) | <.001 | 0.730 | 0.082 (0.014,0.160) | 0.098±0.418 | 0.90 (0.62,1.17) | <.001 | 0.801 | 0.040 (0.016,0.064) |
| CDR 0.5 only | 0.186±0.322 | 2.26 (1.17,3.35) | <.001 | 0.691 | 0.066 (0.005,0.139) | 0.061±0.512 | 0.69 (0.33,1.04) | <.001 | 0.691 | 0.028 (−.000,0.066) |
1
Absolute concordance estimated from 100 bootstrap replicates of the median 10-fold cross-validated rank concordance from 20 random permutations of each bootstrap replicate.
2
Change in median 10-fold cross-validated rank concordance above that of the best baseline model identified for a given bootstrap replicate.
3
Simple percentiles from the bootstrap distribution of change in median 10-fold cross-validated rank concordance.