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. Author manuscript; available in PMC: 2013 Sep 23.
Published in final edited form as: Transplantation. 2006 Dec 15;82(11):1510–1517. doi: 10.1097/01.tp.0000243168.53126.d2

FIGURE 2.

FIGURE 2

Histological assessment of islet allografts. Serial kidney sections were prepared 12 days after islet allograft transplantation. H&E staining showed high-grade cellular rejection with dense tissue infiltration by mononuclear cells in untreated recipients (A). Recipients receiving CTLA4/Fc evidenced a decreased tissue infiltration with some islets preserved (B). Recipients treated with IL-15mutant/Fcγ2a present a rather normal histology with few mononuclear cell infiltrates and intact islets (C). Insulin staining is absent in untreated recipients (D), a result of complete destruction of the islets. In contrast, both CTLA4/Fc and IL-15 mutant/Fcγ2a treated recipients maintained a high level of insulin production (E and F, respectively) (Cryostat sections, hematoxylin counterstain, × 100 magnifications). These are representative sections from two allografts from each treatment group.